Runtime

To use vertex animation textures in your game, you can use one of the following systems:

Use this if you need fine-grained control over how your instances are rendered. You should also be willing to configure it yourself for optimization.
About ISM or HISM

Abstracts ISM and HISM in a properly optimized way. Provides Blueprint functions to render instances. It is easy to use, but lacks some of the flexibility that using ISM / HISM itself provides.
About Vertex Animation Subsystem

Renders instances on top of your actors. Useful for individual actor logic, but lacks performance due to actor overhead.
About Vertex Animation Instance